[Aspergillus spondylodiscitis. Apropos of 5 cases].

Abstract

Five cases of Aspergillus discitis in male patients are reported. Three patients had impaired immune responses as a result of immunosuppressive therapy following a heart transplant (two cases) or hairy cell leukemia (one case). Two patients had a recent history of mycobacterial infection. All five patients were hospitalized for severe spinal pain suggestive of an inflammatory disease with no neurological abnormalities. Erythrocyte sedimentation rate was elevated in every case. The diagnosis of discitis was suspected on spinal roentgenograms and established by computed tomography and/or magnetic resonance imaging. In three patients the spine was the only site of Aspergillus infection (lumbar discitis in two cases and thoracic discitis in one case). One patient developed Aspergillus infection of several disks (L1-L2, L2-L3, and L4-L5) after Aspergillus endocarditis with embolization to the left lower limb. Another patient developed discitis after an Aspergillus lung infection. In every case, Aspergillus fumigatus was recovered in cultures of specimens harvested by a percutaneous needle biopsy of the intervertebral disk. All five patients were treated by itraconazole which was given as single drug therapy in one case and in combination with 5-flucytosine and amphotericin B in four cases. Recovery was achieved in every case after four to six months of this drug therapy. In contrast to most previously reported cases, none of the five patients reported herein required surgical treatment. Efficacy of conservative treatment in this study may be related to the use of itraconazole in every case.(ABSTRACT TRUNCATED AT 250 WORDS)

• Authors: B Cortet, X Deprez, R Triki, C Savage, R M Flipo, B Duquesnoy, B Delcambre
• Journal: Revue du rhumatisme (Ed. francaise : 1993) (Rev Rhum Ed Fr) Vol. 60 Issue 1 Pg. 37-44 (Jan 1993) ISSN: 1169-8330 [Print] France
• Vernacular Title: Les spondylodiscites aspergillaires. A propos de cinq observations.
• PMID: 8242025 (Publication Type: Case Reports, Journal Article, Review)

Chemical References

• Antifungal Agents
• Itraconazole
• Amphotericin B
• Flucytosine

Topics

• Adult
• Amphotericin B (therapeutic use)
• Antifungal Agents (therapeutic use)
• Aspergillosis (complications, drug therapy, microbiology)
• Aspergillus fumigatus
• Discitis (drug therapy, etiology, microbiology)
• Flucytosine (therapeutic use)
• Humans
• Immunocompromised Host
• Itraconazole (pharmacology, therapeutic use)
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Tomography, X-Ray Computed