Abstract | BACKGROUND: Advances in our understanding of the molecular genetics of lymphocyte antigen receptors (B-cell immunoglobulin and T-cell antigen receptor), have led to the application of molecular biologic techniques to molecularly characterize lymphocytic infiltrates of the skin. Molecular diagnosis refers to the application of these techniques as a diagnostic aid in the clinicopathologic evaluation of cutaneous lymphocytic infiltrates. OBSERVATION: CONCLUSIONS: Molecular studies have enormous research value, providing new means to explore the pathogenesis and clonal evolution of lymphoproliferative skin diseases. Presently, however, they have limited applications as an independent diagnostic tool. As our understanding of the clinical and biologic significance of the molecular detection of clonal lymphocyte populations in the skin expands and as the application of polymerase chain reaction amplification provides us with greater detection sensitivity and specificity, the clinical utility of molecular diagnosis of lymphocytic infiltrates of the skin will be enhanced.
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Authors | J M Weinberg, A H Rook, S R Lessin |
Journal | Archives of dermatology
(Arch Dermatol)
Vol. 129
Issue 11
Pg. 1491-500
(Nov 1993)
ISSN: 0003-987X [Print] United States |
PMID | 8239706
(Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
- Antibodies, Monoclonal
- Genetic Markers
- Receptors, Antigen, B-Cell
- Receptors, Antigen, T-Cell
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Topics |
- Antibodies, Monoclonal
- Gene Rearrangement, T-Lymphocyte
(genetics)
- Genetic Markers
- Humans
- Leukemic Infiltration
- Lymphoproliferative Disorders
(genetics, immunology, pathology, therapy)
- Molecular Biology
- Polymerase Chain Reaction
- Receptors, Antigen, B-Cell
(immunology)
- Receptors, Antigen, T-Cell
(immunology)
- Skin
(pathology)
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