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Hypothalamic involvement in stress-induced hypocalcemia in rats.

Abstract
Although hormonal regulation of blood calcium homeostasis has been intensively investigated in the peripheral organs, the involvement of the central nervous system in calcium regulation is still poorly understood. In the present study, we found that (1) bilateral lesions of the ventromedial nucleus of the hypothalamus (VMH), but not those of the paraventricular hypothalamic nucleus or the lateral hypothalamic area, eliminated immobilization (IMB)-induced hypocalcemia, and (2) electrical stimulation of the VMH decreased the blood calcium level. The results suggest that the VMH has a hypocalcemic function and plays a role in IMB-induced hypocalcemia.
AuthorsS Aou, J Ma, T Hori
JournalNeuroscience letters (Neurosci Lett) Vol. 158 Issue 2 Pg. 197-200 (Aug 20 1993) ISSN: 0304-3940 [Print] Ireland
PMID8233094 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Calcium
Topics
  • Animals
  • Calcium (blood)
  • Electric Stimulation
  • Female
  • Hypocalcemia (blood, etiology, metabolism)
  • Hypothalamic Area, Lateral (anatomy & histology, physiology)
  • Hypothalamus (physiology)
  • Immobilization
  • Paraventricular Hypothalamic Nucleus (anatomy & histology, cytology, physiology)
  • Rats
  • Rats, Wistar
  • Stress, Psychological (complications, metabolism, physiopathology)
  • Ventromedial Hypothalamic Nucleus (anatomy & histology, cytology, physiology)

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