Abstract |
Areas under the fever curves of guinea pigs inoculated with Rocky Mountain spotted fever vaccine over a restricted dose range and infected with a standardized dose of Rickettsia rickettsii varied linearly with log10 dose of vaccine. A calculator was programmed to plot fever curves and calculate the vaccine dose that reduced the fever of infected animals by 50%.
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Authors | R L Anacker, R F Smith, R E Mann, M A Hamilton |
Journal | Journal of clinical microbiology
(J Clin Microbiol)
Vol. 4
Issue 3
Pg. 309-11
(Sep 1976)
ISSN: 0095-1137 [Print] United States |
PMID | 823177
(Publication Type: Journal Article)
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Chemical References |
- Rickettsial Vaccines
- Vaccines
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Topics |
- Animals
- Body Temperature
- Drug Evaluation, Preclinical
- Guinea Pigs
- Injections, Intraperitoneal
- Male
- Rickettsia rickettsii
(immunology)
- Rickettsial Vaccines
(administration & dosage)
- Rocky Mountain Spotted Fever
(prevention & control)
- Vaccines
(administration & dosage)
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