Abstract |
The efficacy of multiple dose oral activated charcoal (OAC) therapy for neonatal hyperbilirubinemia was prospectively studied in 30 jaundiced newborns receiving phototherapy, randomly assigned to a study group (n = 14) or control group (n = 16). The study group received OAC before meals with a total amount of 8.5 +/- 0.85 gms (M +/- SEM). Serum bilirubin levels upon initiation of phototherapy were (M +/- SEM) 265 +/- 8 and 253 +/- 4 mumol/L respectively. After 24 hours there was no significant decrease in serum bilirubin levels in the control group (M +/- SEM = 240 +/- 8 mumol/L) but bilirubin levels of the study group decreased (M +/- SEM = 235 +/- 7 mumol/L, p < 0.02). At 48 hours serum bilirubin levels were significantly lower than baseline values in both groups. However, the decline in bilirubin levels in the study group (M +/- SEM = 56 +/- 10 mumol/L) was greater than that of the controls (M +/- SEM = 21 +/- 10 mumol/L p < 0.02). Oral activated charcoal seems to be an effective adjunct to phototherapy in the treatment of neonatal hyperbilirubinemia.
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Authors | Y Amitai, M Regev, I Arad, O Peleg, M Boehnert |
Journal | Journal of perinatal medicine
(J Perinat Med)
Vol. 21
Issue 3
Pg. 189-94
( 1993)
ISSN: 0300-5577 [Print] Germany |
PMID | 8229609
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Charcoal
- Nickel
- Bilirubin
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Topics |
- Administration, Oral
- Bilirubin
(blood)
- Charcoal
(administration & dosage, adverse effects, therapeutic use)
- Humans
- Infant, Newborn
- Jaundice, Neonatal
(blood, therapy)
- Kinetics
- Nickel
(blood)
- Phototherapy
- Prospective Studies
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