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Investigation of the usefulness of the photodynamic reaction for the purging of bone marrow from metastatic neuroblastoma cells.

Abstract
The neuroblastoma cell lines SK-N-LO, SK-PN-DW and IMR 5 were stained with Merocyanine 540 and exposed to white light. 99% of clonogenic tumour cells were destroyed while 60% of bone marrow progenitor cells survived this treatment.
AuthorsA Köhler, A Müller, F Zintl
JournalJournal of photochemistry and photobiology. B, Biology (J Photochem Photobiol B) Vol. 19 Issue 3 Pg. 227-9 (Aug 1993) ISSN: 1011-1344 [Print] Switzerland
PMID8229464 (Publication Type: Journal Article)
Chemical References
  • Photosensitizing Agents
  • Pyrimidinones
  • merocyanine dye
Topics
  • Bone Marrow (drug effects, pathology, radiation effects)
  • Bone Marrow Purging
  • Cell Survival
  • Hematopoietic Stem Cells (drug effects, radiation effects)
  • Humans
  • Light
  • Neuroblastoma (drug therapy, pathology, secondary)
  • Photochemotherapy
  • Photosensitizing Agents (therapeutic use)
  • Pyrimidinones (therapeutic use)
  • Tumor Cells, Cultured

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