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Serum pepsinogens as markers of response to therapy for Helicobacter pylori gastritis.

Abstract
We have investigated the effect of therapy for Helicobacter pylori gastritis on serum concentrations of pepsinogen I and II in 43 patients. In the 22 patients in whom therapy resulted in dramatic decrease in gastritis scores and in clearance of the bacteria, there was a highly significant (P = 0.0001) fall in mean serum pepsinogen II from 13.3 +/- 0.8 to 7.9 +/- 0.7 micrograms/liter, and a less pronounced fall in pepsinogen I from 89.0 +/- 5.9 to 78.5 +/- 0.4 micrograms/liter (P = 0.01). These changes resulted in a significant (P = 0.01) increase in the pepsinogen I/II ratio. In contrast, nonsignificant declines of 3.5% and 11.6% were observed in mean pepsinogen I and II levels in the 21 patients whose gastritis failed to resolve histologically and whose infection did not clear. These findings suggest that serum pepsinogen levels, especially pepsinogen II, are a new tool that may be found to be clinically useful in evaluation of treatment outcome in patients with H. pylori-associated gastritis.
AuthorsF M Hunter, P Correa, E Fontham, B Ruiz, M Sobhan, I M Samloff
JournalDigestive diseases and sciences (Dig Dis Sci) Vol. 38 Issue 11 Pg. 2081-6 (Nov 1993) ISSN: 0163-2116 [Print] United States
PMID8223084 (Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S.)
Chemical References
  • Organometallic Compounds
  • Pepsinogens
  • Salicylates
  • Metronidazole
  • bismuth subsalicylate
  • Nitrofurantoin
  • Bismuth
Topics
  • Adult
  • Biopsy
  • Bismuth (therapeutic use)
  • Female
  • Gastric Mucosa (pathology)
  • Gastritis (drug therapy, microbiology)
  • Helicobacter Infections (blood, diagnosis, drug therapy)
  • Helicobacter pylori (isolation & purification)
  • Humans
  • Male
  • Metronidazole (therapeutic use)
  • Middle Aged
  • Nitrofurantoin (therapeutic use)
  • Organometallic Compounds (therapeutic use)
  • Pepsinogens (blood)
  • Salicylates (therapeutic use)

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