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Therapeutic effects of an androgenic preparation on myocardial ischemia and cardiac function in 62 elderly male coronary heart disease patients.

Abstract
The elevated estradiol/testosterone (E2/T) ratio had been proved to be a risk factor for coronary heart disease (CHD) in elderly men. We conducted a randomized placebo controlled crossover study on the effects of a new androgenic preparation "Andriol" in 62 elderly men with CHD over a period of 2.5 months. The results showed significant differences between Andriol- and placebo-treated groups at the end of this period: in the former, serum T level was elevated significantly (P < 0.001), E2 level was unchanged (P > 0.05), E2/T ratio was reduced (P < 0.05), angina pectoris (AP) was relieved (total effective rate, 77.4%), and myocardial ischemia in ECG and Holter recordings were improved (total effective rate, respectively 68.8% and 75%). Doppler echocardiography showed that 12 parameters of cardiac function were unchanged in both groups. No obvious side effect was found in those who took Andriol.
AuthorsS Z Wu, X Z Weng
JournalChinese medical journal (Chin Med J (Engl)) Vol. 106 Issue 6 Pg. 415-8 (Jun 1993) ISSN: 0366-6999 [Print] China
PMID8222891 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
Chemical References
  • Testosterone
  • Estradiol
  • testosterone undecanoate
Topics
  • Aged
  • Angina Pectoris (blood, drug therapy)
  • Coronary Disease (blood, drug therapy, physiopathology)
  • Estradiol (blood)
  • Heart (physiopathology)
  • Humans
  • Male
  • Middle Aged
  • Testosterone (analogs & derivatives, blood, therapeutic use)

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