Abstract | OBJECTIVES: METHODS:
Myocardial infarctions (n = 31) were induced and sham operations (n = 25) were performed on Wistar rats, and the rats were monitored for three months. Aortic and pulmonary cGMP contents were measured, as the aorta is mainly matrix and smooth muscle cells, and the lung is particularly rich in capillaries, hence in endothelial cells. The concentrations of the other second messenger cyclic adenosine monophosphate (cAMP) was also determined, as were those of cGMP dependent protein kinase in the arteries. RESULTS: 17 of the 31 rats with myocardial infarction had oedema. The total heart weight to body weight ratio and the ratio of the myocardium haemodynamically upstream from the infarcted left ventricle to body weight were increased in proportion to the infarct size. Plasma atrial natriuretic peptide and plasma and urinary cGMP concentrations were increased in proportion to the degree of heart failure (p < 0.0001). The pulmonary cGMP concentration was significantly higher in the rats with myocardial infarction than in the control group (p < 0.0001). Pulmonary cGMP concentrations were correlated with the plasma concentrations of atrial natriuretic peptide and cGMP (r2 = 0.59 and 0.66 respectively, p < 0.0001). The cGMP, cAMP, and cGMP, and cGMP dependent kinase concentrations in the aortic wall of rats with myocardial infarctions were the same as in control rats. CONCLUSIONS:
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Authors | J F Arnal, F Hofmann, J B Michel |
Journal | Cardiovascular research
(Cardiovasc Res)
Vol. 27
Issue 6
Pg. 1094-100
(Jun 1993)
ISSN: 0008-6363 [Print] England |
PMID | 8221770
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Atrial Natriuretic Factor
- Cyclic GMP
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Topics |
- Animals
- Aorta
(metabolism)
- Atrial Natriuretic Factor
(blood, pharmacology)
- Blood Pressure
(physiology)
- Body Weight
(physiology)
- Cyclic GMP
(blood, metabolism)
- Heart Failure
(metabolism, physiopathology)
- Male
- Myocardial Infarction
(pathology, physiopathology)
- Myocardium
(pathology)
- Organ Size
- Rats
- Rats, Wistar
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