Abstract |
In this article the effect of vitamin E on two extrapyramidal disorders, tardive dyskinesia and Parkinson's disease, is reviewed. After a brief description of the symptoms, the current hypotheses for the pathogenesis of these diseases are described. A summary of the clinical research that has been done to establish the effectiveness of vitamin E is given. In tardive dyskinesia four clinical trials (double-blind, placebo-controlled) showed improvement in the symptoms with vitamin E in doses of up to 1,600 IU/day. Preliminary studies concerning Parkinson's disease suggested that vitamin E (2,000 IU/day) probably cannot prevent the development of the disease. It was suggested that vitamin E is able to slow the progression of the illness. The results from a large double-blind, placebo-controlled clinical trial, however, did not show any beneficial effect of vitamin E in Parkinson's disease.
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Authors | L Bischot, G Van den Brink, A J Porsius |
Journal | Pharmacy world & science : PWS
(Pharm World Sci)
Vol. 15
Issue 4
Pg. 146-50
(Aug 20 1993)
ISSN: 0928-1231 [Print] Germany |
PMID | 8220297
(Publication Type: Journal Article, Review)
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Chemical References |
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Topics |
- Basal Ganglia Diseases
(drug therapy)
- Humans
- Vitamin E
(therapeutic use)
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