Treatment of perennial allergic rhinitis with cromolyn sodium. Double-blind study on 34 adult patients.
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| Abstract |
A double-blind crossover study was performed on 34 adult patients with perennial allergic rhinitis, using an aqueous solution of 4% cromolyn sodium or a placebo substance six times daily over a 4-wk period with daily documentation of both symptoms and use of symptomatic medications. All patients had markedly positive skin test reactions to at least one antigen. Chemistry screens and IgE serum levels were determined. Significant reductions occurred in the symptom-scores for runny nose, stuffy nose, sneezing, and nose blowing while patients were on cromolyn treatment (p less than 0.005). Likewise, while on treatment, there was a significant reduction in the consumption of antihistamines. In an attempt to differentiate between good and poor cromolyn responders by clinical and laboratory parameters, we found that (1) patients with high IgE levels responded better than those with low IgE levels, (2) patients with markedly positive skin test reactions to epidermoids and to foods responded better than those with pollen allergy, and (3) females appeared to have a significantly better drug response than males. Age did not play a role in drug response, nor did drug sequence (placebo-active or active-placebo).
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| Authors | R H Cohan, F L Bloom, R B Rhoades, H J Wittig, L D Haugh |
| Journal | The Journal of allergy and clinical immunology (J Allergy Clin Immunol) Vol. 58 Issue 1 PT. 2 Pg. 121-8 (Jul 1976) ISSN: 0091-6749 [Print] United States |
| PMID | 821986 (Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial) |
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