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Epidural versus subcutaneous administration of alfentanil for the management of postoperative pain.

Abstract
This study was designed to compare the efficacy and serum concentrations of alfentanil given subcutaneously (SQ) or epidurally (EPID) for treatment of postoperative pain. Following abdominal surgery, patients (n = 12) were randomly assigned to receive double-blind SQ or EPID alfentanil over 24 h via the allocated route (1 mg along with 0.2 mg/h and 0.2-mg boluses on demand) and saline via the other route of administration using a patient-controlled analgesic (PCA) delivery system. Significantly less EPID alfentanil produced better quality analgesia and fewer side effects than SQ alfentanil. The fact that EPID analgesia was maintained with serum alfentanil concentrations less than those producing systemic analgesia confirms the spinal site of the EPID alfentanil action.
AuthorsJ Chrubasik, S Chrubasik, Y Ren, J Schulte-Mönting, E Martin
JournalAnesthesia and analgesia (Anesth Analg) Vol. 78 Issue 6 Pg. 1114-8 (Jun 1994) ISSN: 0003-2999 [Print] United States
PMID8198267 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)
Chemical References
  • Alfentanil
Topics
  • Abdomen (surgery)
  • Adult
  • Aged
  • Alfentanil (administration & dosage, therapeutic use)
  • Analgesia, Epidural
  • Analgesia, Patient-Controlled
  • Double-Blind Method
  • Female
  • Humans
  • Injections, Subcutaneous
  • Male
  • Middle Aged
  • Pain, Postoperative (prevention & control)

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