First established pregnancy and birth after induction of ovulation with recombinant human follicle-stimulating hormone in polycystic ovary syndrome.

Abstract

This case report describes the first established pregnancy and birth after induction of ovulation with recombinant human follicle-stimulating hormone (FSH) in a woman suffering from chronic clomiphene-resistant anovulation due to polycystic ovary syndrome (elevated serum luteinizing hormone and testosterone concentrations together with polycystic ovaries). Starting on day 3 of a progestagen withdrawal bleeding, 75 IU of rFSH was administered i.m. daily until a single preovulatory follicle was seen upon transvaginal ultrasound examination at day 13. Ovulation was induced by a single i.m. administration of 10,000 IU of human chorionic gonadotrophin, after which a viable singleton pregnancy was revealed at a gestational age of 6 weeks. The course of pregnancy and labour was uneventful and no abnormalities were found upon a paediatric examination.

• Authors: H J van Dessel, P F Donderwinkel, H J Coelingh Bennink, B C Fauser
• Journal: Human reproduction (Oxford, England) (Hum Reprod) Vol. 9 Issue 1 Pg. 55-6 (Jan 1994) ISSN: 0268-1161 [Print] England
• PMID: 8195351 (Publication Type: Case Reports, Journal Article)

Chemical References

• Recombinant Proteins
• Follicle Stimulating Hormone

Topics

• Female
• Follicle Stimulating Hormone (therapeutic use)
• Humans
• Infertility, Female (drug therapy, etiology)
• Ovulation Induction (methods)
• Polycystic Ovary Syndrome (complications)
• Pregnancy
• Pregnancy Outcome
• Recombinant Proteins (therapeutic use)