Abstract |
The activity of dimethylaminomethyl-10-hydroxycamptothecin ( topotecan) was evaluated against a panel of xenografts derived from ependymomas (D528 EP, D612 EP), childhood high-grade gliomas (D-456 MG, D-212 MG), adult high-grade gliomas (D-245 MG, D-54 MG), and medulloblastomas (D425 Med) growing s.c. and i.c. (intracranially) in athymic nude mice. Topotecan was given at a dose of 1.9 mg/kg by i.p. injection in 0.9% saline using a volume of 90 ml/m2 on days 1-5 and 8-12, which represents the dose lethal to 10% of treated animals. Topotecan was active in the therapy of all s.c. xenografts tested, with growth delays ranging from 6.3 days in D-54 MG to 55.7 days in D528 EP. Topotecan produced statistically significant tumor regressions in D425 Med, D-456 MG, D-245 MG, D528 EP, and D612 EP. No tumor regression was seen in any control animal. Statistically significant increases in median survival were seen in the two i.c. xenografts--D-456 MG (28.6% increase) and D-54 MG (39% increase)--treated with topotecan. These studies suggest that topotecan may be an important new addition to the therapy of central nervous system tumors.
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Authors | H S Friedman, P J Houghton, S C Schold, S Keir, D D Bigner |
Journal | Cancer chemotherapy and pharmacology
(Cancer Chemother Pharmacol)
Vol. 34
Issue 2
Pg. 171-4
( 1994)
ISSN: 0344-5704 [Print] Germany |
PMID | 8194169
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Antineoplastic Agents
- Topotecan
- Camptothecin
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Topics |
- Adult
- Animals
- Antineoplastic Agents
(therapeutic use, toxicity)
- Camptothecin
(analogs & derivatives, therapeutic use, toxicity)
- Central Nervous System Neoplasms
(drug therapy, mortality)
- Child
- Drug Screening Assays, Antitumor
- Female
- Humans
- Mice
- Mice, Inbred BALB C
- Neoplasm Transplantation
- Random Allocation
- Time Factors
- Topotecan
- Transplantation, Heterologous
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