[The effects of small dose midazolam in patients to reduce the uncomfortable feeling during epidural block procedure].

The effects of small dose midazolam to reduce the uncomfortable feeling during epidural block procedure were studied. All 160 patients (ASA I approximately II) were premedicated with intramuscular (I.M.) atropine sulfate 0.5 mg and hydroxyzine 50 mg. To relieve pain and anxiety during epidural block procedure, small dose midazolam (1 mg; 80 patients) was given intravenously in the operating room before epidural procedure. After epidural block, patients were anesthetized with nitrous oxide-oxygen-isoflurane or nitrous oxide-oxygen-sevoflurane. The following day, patient's self-assessments of pain during epidural block procedure were categorized as good and fair. Midazolam 1 mg was effective in the males (from 45% to 10%) and tended to allay patients' pain feeling in the females (from 40% to 23%). To investigate the uncomfortable feeling 1 further asked the patients whether epidural block procedure was more noxious than I.M. premedication or not. Noxious feeling was expressed in more I.M. premedicated patients (78%) than in epidural block procedure patients (48%). These results suggest that small dose midazolam is effective to relieve patients' uncomfortable feeling due to its sedative and antianxiety effects.
AuthorsT Kasaba
JournalMasui. The Japanese journal of anesthesiology (Masui) Vol. 43 Issue 4 Pg. 547-50 (Apr 1994) ISSN: 0021-4892 [Print] JAPAN
PMID8189620 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Midazolam
  • Adult
  • Aged
  • Anesthesia, Epidural
  • Anxiety (drug therapy)
  • Female
  • Humans
  • Injections, Intravenous
  • Male
  • Midazolam (administration & dosage)
  • Middle Aged
  • Pain (drug therapy, psychology)
  • Patient Satisfaction

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