A 6.5-Mb yeast artificial chromosome contig incorporating 33 DNA markers on the human X chromosome at Xq22.

Abstract

The Xq22 region of the human X chromosome contains genes for a number of inherited disorders. Sixty-nine yeast artificial chromosome clones have been isolated and assembled into a 6.5-Mb contig that contains 33 DNA markers localized to this region. This contig extends distally from DXS366 to beyond DXS87 and includes the genes involved in X-linked agammaglobulinemia (btk), Fabry disease (GLA), and Pelizaeus-Merzbacher disease (PLP). The order of markers in this contig is consistent with the known genetic and physical mapping information of Xq22. This cloned material provides a source from which to isolate other genes located in this part of the X chromosome.

• Authors: D Vetrie, E Kendall, A Coffey, S Hassock, J Collins, C Todd, H Lehrach, M Bobrow, D R Bentley, A Harris
• Journal: Genomics (Genomics) Vol. 19 Issue 1 Pg. 42-7 (Jan 01 1994) ISSN: 0888-7543 [Print] United States
• PMID: 8188239 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Genetic Markers

Topics

• Adult
• Agammaglobulinemia (genetics)
• Chromosome Walking
• Chromosomes, Artificial, Yeast
• Diffuse Cerebral Sclerosis of Schilder (genetics)
• Fabry Disease (genetics)
• Gene Library
• Genetic Markers
• Humans
• X Chromosome