Abstract | BACKGROUND: METHODS: Efficacy and tolerability of pantoprazole (40 mg at breakfast) and ranitidine (300 mg at bedtime) in the treatment of uncomplicated acute duodenal ulcer were compared in a double-blind randomized multicentre trial. RESULTS: Of 202 outpatients who entered the study, 185 terminated the treatment without violation of the protocol. After 2 weeks of treatment, healing rates (protocol correct) with pantoprazole and ranitidine were 81 and 53%, respectively (P < 0.001), the corresponding results after 4 weeks were 97 and 83% (P < 0.01). Pantoprazole was more effective with respect to symptom relief. Both treatments were well tolerated. CONCLUSION:
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Authors | G Judmaier, H R Koelz |
Journal | Alimentary pharmacology & therapeutics
(Aliment Pharmacol Ther)
Vol. 8
Issue 1
Pg. 81-6
(Feb 1994)
ISSN: 0269-2813 [Print] England |
PMID | 8186350
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Benzimidazoles
- Proton Pump Inhibitors
- Sulfoxides
- Ranitidine
- Pantoprazole
- Omeprazole
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Topics |
- 2-Pyridinylmethylsulfinylbenzimidazoles
- Administration, Oral
- Adult
- Aged
- Benzimidazoles
(administration & dosage, therapeutic use)
- Double-Blind Method
- Drug Administration Schedule
- Duodenal Ulcer
(drug therapy)
- Female
- Humans
- Male
- Middle Aged
- Omeprazole
(analogs & derivatives)
- Pantoprazole
- Proton Pump Inhibitors
- Ranitidine
(administration & dosage, therapeutic use)
- Sulfoxides
(administration & dosage, therapeutic use)
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