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Comparison of pantoprazole and ranitidine in the treatment of acute duodenal ulcer. Pantoprazole-Duodenal Ulcer-Study Group.

AbstractBACKGROUND:
Pantoprazole is a new substituted benzimidazole that blocks the H+/K(+)-ATPase in the gastric mucosa and thus inhibits acid secretion.
METHODS:
Efficacy and tolerability of pantoprazole (40 mg at breakfast) and ranitidine (300 mg at bedtime) in the treatment of uncomplicated acute duodenal ulcer were compared in a double-blind randomized multicentre trial.
RESULTS:
Of 202 outpatients who entered the study, 185 terminated the treatment without violation of the protocol. After 2 weeks of treatment, healing rates (protocol correct) with pantoprazole and ranitidine were 81 and 53%, respectively (P < 0.001), the corresponding results after 4 weeks were 97 and 83% (P < 0.01). Pantoprazole was more effective with respect to symptom relief. Both treatments were well tolerated.
CONCLUSION:
Pantoprazole 40 mg at breakfast is superior to ranitidine 300 mg at bedtime in the short-term treatment of acute, uncomplicated duodenal ulcer.
AuthorsG Judmaier, H R Koelz
JournalAlimentary pharmacology & therapeutics (Aliment Pharmacol Ther) Vol. 8 Issue 1 Pg. 81-6 (Feb 1994) ISSN: 0269-2813 [Print] England
PMID8186350 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Benzimidazoles
  • Proton Pump Inhibitors
  • Sulfoxides
  • Ranitidine
  • Pantoprazole
  • Omeprazole
Topics
  • 2-Pyridinylmethylsulfinylbenzimidazoles
  • Administration, Oral
  • Adult
  • Aged
  • Benzimidazoles (administration & dosage, therapeutic use)
  • Double-Blind Method
  • Drug Administration Schedule
  • Duodenal Ulcer (drug therapy)
  • Female
  • Humans
  • Male
  • Middle Aged
  • Omeprazole (analogs & derivatives)
  • Pantoprazole
  • Proton Pump Inhibitors
  • Ranitidine (administration & dosage, therapeutic use)
  • Sulfoxides (administration & dosage, therapeutic use)

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