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Contrast media algogenic potential in peripheral arteriography. Potentiation of bradykinin-induced pain in the rat.

AbstractRATIONALE AND OBJECTIVES:
Contrast media (CM) with minimal algogenic (pain causing) potential in animal models of peripheral arteriography are still able to produce vascular pain in humans; the poor predictive value of preclinical evaluation led us to develop a more sensitive method based on CM potentiation of bradykinin effects in the rat.
METHODS:
Behavioral pain responses and histologic alterations of the arteries were determined after intrafemoral injection of bradykinin to saline- or CM-pretreated rats. Pain reactions were compared with those elicited by single and repeated CM injections.
RESULTS:
Contrast media enhanced bradykinin-induced pain was dose dependent with the following potency order: iopamidol > iopromide > ZK 139129 > ZK 119095. Vasodilation and alterations of the arterial internal layer also were seen. Iopromide produced this sensitization at doses that did not elicit evident pain reactions per se.
CONCLUSION:
The method proved to be a highly sensitive preclinical discriminant of CM algogenic potential.
AuthorsL F Alguacil, C Gonzalez, F Böhle, I Jimenez, C Alamo, J L Martin
JournalInvestigative radiology (Invest Radiol) Vol. 29 Issue 3 Pg. 294-300 (Mar 1994) ISSN: 0020-9996 [Print] United States
PMID8175303 (Publication Type: Journal Article)
Chemical References
  • Contrast Media
  • Bradykinin
Topics
  • Angiography
  • Animals
  • Bradykinin (adverse effects)
  • Contrast Media (adverse effects)
  • Dose-Response Relationship, Drug
  • Female
  • Femoral Artery (drug effects)
  • Male
  • Osmolar Concentration
  • Pain (chemically induced)
  • Pain Measurement
  • Rats
  • Rats, Sprague-Dawley

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