Abstract | RATIONALE AND OBJECTIVES:
Contrast media (CM) with minimal algogenic ( pain causing) potential in animal models of peripheral arteriography are still able to produce vascular pain in humans; the poor predictive value of preclinical evaluation led us to develop a more sensitive method based on CM potentiation of bradykinin effects in the rat. METHODS: Behavioral pain responses and histologic alterations of the arteries were determined after intrafemoral injection of bradykinin to saline- or CM-pretreated rats. Pain reactions were compared with those elicited by single and repeated CM injections. RESULTS:
Contrast media enhanced bradykinin-induced pain was dose dependent with the following potency order: iopamidol > iopromide > ZK 139129 > ZK 119095. Vasodilation and alterations of the arterial internal layer also were seen. Iopromide produced this sensitization at doses that did not elicit evident pain reactions per se. CONCLUSION: The method proved to be a highly sensitive preclinical discriminant of CM algogenic potential.
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Authors | L F Alguacil, C Gonzalez, F Böhle, I Jimenez, C Alamo, J L Martin |
Journal | Investigative radiology
(Invest Radiol)
Vol. 29
Issue 3
Pg. 294-300
(Mar 1994)
ISSN: 0020-9996 [Print] United States |
PMID | 8175303
(Publication Type: Journal Article)
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Chemical References |
- Contrast Media
- Bradykinin
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Topics |
- Angiography
- Animals
- Bradykinin
(adverse effects)
- Contrast Media
(adverse effects)
- Dose-Response Relationship, Drug
- Female
- Femoral Artery
(drug effects)
- Male
- Osmolar Concentration
- Pain
(chemically induced)
- Pain Measurement
- Rats
- Rats, Sprague-Dawley
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