Abstract |
The effect of chronic in utero hypoxia on voltage-sensitive Na+ channels in newborn rat brain was investigated by means of ligand binding and autoradiography with [3H] saxitoxin (STX, Na+ channel ligand). We found that: (a) binding properties were different between hypoxic and control brains with alinear Scatchard plots in hypoxic brain versus linear ones in the control; (b) STX binding density increased greatly in response to hypoxic stimulation; and (c) the hypoxia-induced increase in STX binding was heterogeneous in various brain areas. We conclude that chronic hypoxia in utero alters the expression of Na+ channels and induces an up-regulation of Na+ channel density as a function of brain area. This is the first report of this phenomenon and we believe that the increased Na+ channels may play an important role in the etiology of neurological disorders such as epilepsy.
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Authors | Y Xia, G G Haddad |
Journal | Brain research
(Brain Res)
Vol. 635
Issue 1-2
Pg. 339-44
(Jan 28 1994)
ISSN: 0006-8993 [Print] Netherlands |
PMID | 8173974
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Animals
- Animals, Newborn
(metabolism)
- Chronic Disease
- Female
- Fetal Hypoxia
(metabolism)
- Hypoxia, Brain
(metabolism)
- Pregnancy
- Radioligand Assay
- Rats
- Rats, Sprague-Dawley
- Sodium Channels
(metabolism)
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