Abstract |
We present six patients with acute fulminant episodes of CNS inflammatory demyelination who responded to therapeutic plasmapheresis after failing a course of high-dose methylprednisolone administered IV. Neurologic improvement occurred in three of the patients following the second plasmapheresis. Dramatic improvement in motor function (four patients) and language (two patients) began within 2 to 14 days and persisted during the 6 to 35 months (mean, 15 months) of follow-up. Results of this uncontrolled study suggest that plasmapheresis in the absence of other immunosuppressive drugs may have a role in the treatment of severe episodes of inflammatory demyelination in a select subset of MS patients.
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Authors | M Rodriguez, W E Karnes, J D Bartleson, A A Pineda |
Journal | Neurology
(Neurology)
Vol. 43
Issue 6
Pg. 1100-4
(Jun 1993)
ISSN: 0028-3878 [Print] United States |
PMID | 8170550
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Demyelinating Diseases
(etiology, therapy)
- Female
- Follow-Up Studies
- Humans
- Male
- Methylprednisolone
(therapeutic use)
- Middle Aged
- Multiple Sclerosis
(complications)
- Plasmapheresis
- Retrospective Studies
- Treatment Outcome
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