Abstract | BACKGROUND: METHODS: Sixty-two patients with a primary DSM-III-R diagnosis of OCD received placebo fluvoxamine for 1 week, followed by 8 weeks of active fluvoxamine. Thirty-four of these patients were refractory to fluvoxamine and were randomized in a double-blind fashion to 4 weeks of treatment with either haloperidol (n = 17) or placebo (n = 17) added to ongoing fluvoxamine treatment. The placebo-treated group included five women and 12 men, six inpatients and 11 outpatients, and eight patients with a comorbid chronic tic disorder. The haloperidol-treated group consisted of two women and 15 men, three inpatients and 14 outpatients, and seven patients with a comorbid chronic tic disorder. All 34 patients completed the entire study. The Yale-Brown Obsessive Compulsive Scale (Y-BOCS) and the Clinical Global Impression scale were the principal measures of treatment outcome. RESULTS:
Haloperidol addition was significantly better than placebo in reducing the severity of obsessive-compulsive symptoms as measured by the Y-BOCS. Eleven of 17 patients responded to the haloperidol, compared with none of 17 patients given placebo. Eight of eight patients with comorbid chronic tic disorders, such as Tourette's disorder, responded to double-blind haloperidol addition to ongoing fluvoxamine treatment. Haloperidol addition was of little benefit in treating OCD patients without tics. Fluvoxamine blood levels were not related to treatment response. CONCLUSIONS:
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Authors | C J McDougle, W K Goodman, J F Leckman, N C Lee, G R Heninger, L H Price |
Journal | Archives of general psychiatry
(Arch Gen Psychiatry)
Vol. 51
Issue 4
Pg. 302-8
(Apr 1994)
ISSN: 0003-990X [Print] United States |
PMID | 8161290
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Placebos
- Haloperidol
- Fluvoxamine
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Topics |
- Adolescent
- Adult
- Age of Onset
- Behavior Therapy
- Comorbidity
- Double-Blind Method
- Drug Therapy, Combination
- Female
- Fluvoxamine
(therapeutic use)
- Haloperidol
(therapeutic use)
- Humans
- Male
- Middle Aged
- Obsessive-Compulsive Disorder
(drug therapy, epidemiology, psychology)
- Placebos
- Psychiatric Status Rating Scales
- Tic Disorders
(drug therapy, epidemiology, psychology)
- Treatment Outcome
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