Serum bone-type alkaline phosphatase activity in women living in a cadmium-polluted area.

Abstract

To clarify the significance of elevated serum total alkaline phosphatase activity (t-ALP) in persons exposed to environmental cadmium (Cd), the fraction of ALP originating from bone (b-ALP) was assayed using a wheat-germ agglutinin method in 23 men and 20 women in a Cd-polluted area who showed excessive urinary beta 2-microglobulin excretion, and in 21 men and 44 women in a non-polluted area, in addition to 7 patients with itai-itai disease. The fraction of b-ALP increased linearly with the increase in t-ALP in the women, irrespective of Cd-exposure. Elevations of both t-ALP and b-ALP in the Cd-exposed women, including inhabitants of the Cd-polluted area and patients with itai-itai disease, were found with decreases in serum calcium and bone density. It is concluded that elevated serum ALP levels found in Cd-exposed persons reflect the development of Cd-induced bone damage.

• Authors: I Tsuritani, R Honda, M Ishizaki, Y Yamada, K Aoshima, M Kasuya
• Journal: Toxicology letters (Toxicol Lett) Vol. 71 Issue 3 Pg. 209-16 (May 1994) ISSN: 0378-4274 [Print] Netherlands
• PMID: 8160209 (Publication Type: Journal Article)

Chemical References

• Cadmium
• Alkaline Phosphatase
• Calcium

Topics

• Aged
• Alkaline Phosphatase (blood)
• Bone Density
• Bone and Bones (enzymology)
• Cadmium (adverse effects)
• Cadmium Poisoning (blood, etiology)
• Calcium (blood)
• Environmental Exposure (adverse effects)
• Female
• Humans
• Male
• Middle Aged