[The characteristics of the changes in the blood enzyme activity of patients with acute alcoholic psychoses].

Abstract

The serum activity of alanine aminotransferase, aspartate aminotransferase, glutamate dehydrogenase, gamma-glutamyl transferase and creatinine kinase was studied in 81 patients with chronic alcoholism and 31 patients with alcoholic psychoses. Eighty-one healthy apparently non-drinkers served as a control group. It is concluded that when acute alcoholic psychoses develop, patients with chronic alcoholism display a simultaneous increase in the activity of enzymes releasing from damaged muscular and hepatic tissues. This makes the application of a number of the diagnostic criteria developed in classical clinical enzymology impossible. The phenomenon of concurrent increases in the activity of creatine kinase, aspartate aminotransferase and glutamate dehydrogenase by 4 times or more has been proposed to be used as a criteria for identifying alcoholic psychosis in alcoholics.

• Authors: V A Iakovchenko, V V Makarovskiĭ, A V Moshkin
• Journal: Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova (Zh Nevrol Psikhiatr Im S S Korsakova) Vol. 93 Issue 5 Pg. 79-81 ( 1993) ISSN: 1997-7298 [Print] Russia (Federation)
• Vernacular Title: Osobennosti izmeneniia aktivnosti fermentov v krovi bol'nykh ostrymi alkogol'nymi psikhozami.
• PMID: 8154228 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Biomarkers
• Enzymes

Topics

• Acute Disease
• Adult
• Alcoholism (diagnosis)
• Biomarkers (blood)
• Clinical Enzyme Tests
• Enzymes (blood)
• Humans
• Male
• Middle Aged
• Prognosis
• Psychoses, Alcoholic (diagnosis)