HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Epidermal growth factor concentrations in seminal plasma from patients with hypogonadism--changes after hormone replacement.

Abstract
Epidermal growth factor (EGF) content in seminal plasma of 17 patients with androgen deficiency (12 Klinefelter's syndrome and 5 hypogonadotropic hypogonadism) was determined before and after hormone replacement. No significant increase of plasma testosterone level was demonstrated after testosterone administration in Klinefelter's syndrome, although the level in 4 of 5 patients with hypogonadotropic hypogonadism reached the normal range. In 16 patients, except 1 with hypogonadotropic hypogonadism with no increase of blood testosterone level, prostate volume increased after hormone therapy, and volumes after treatment were significantly larger than those before treatment. On the other hand, EGF concentration in seminal plasma remained at the pretreatment level in most patients. It is therefore concluded that although the prostate volume increases to almost normal after treatment, prostate function does not improve in most patients, indicating that in patients with hypogonadotropic hypogonadism fertility potential may remain low, even if they obtain normal seminal parameters after treatment.
AuthorsH Fuse, M Okumura, M Sakamoto, T Kazama, T Katayama
JournalUrologia internationalis (Urol Int) Vol. 52 Issue 1 Pg. 9-13 ( 1994) ISSN: 0042-1138 [Print] Switzerland
PMID8140686 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Chorionic Gonadotropin
  • Testosterone
  • Menotropins
  • Epidermal Growth Factor
  • testosterone enanthate
Topics
  • Adult
  • Chorionic Gonadotropin (therapeutic use)
  • Epidermal Growth Factor (analysis, metabolism)
  • Humans
  • Hypogonadism (drug therapy, metabolism)
  • Klinefelter Syndrome (drug therapy, metabolism)
  • Male
  • Menotropins (therapeutic use)
  • Prostate (physiopathology)
  • Semen (chemistry)
  • Testosterone (analogs & derivatives, metabolism, therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: