[Roxithromycin treatment in patients with chronic lower respiratory tract disease--its clinical efficacy and effect on cytokine].

Abstract

We demonstrated the efficacy of "long term" roxithromycin (RXM) treatment in 15 patients with chronic lower respiratory tract disease (11 with diffuse panbronchiolitis and 4 with sinobronchial syndrome). (1) Fourteen (93.3%) of the 15 patients showed improvement when assessed by the comprehensive improvement score, and they showed significant improvements in PaO2 (74.2 +/- 10.4 Torr to 84.3 +/- 10.9 Torr, p < 0.01), %VC (86.9 +/- 20.2% to 96.0 +/- 21.9%, p < 0.001) and FEV1 (1.81 +/- 0.87 L to 2.14 +/- 1.08 L, p < 0.01) after RXM treatment. (2) Neutrophils accumulated in the pre-RXM treatment bronchoalveolar lavage (BAL) fluid and decreased in BAL fluid of patients responding to RXM treatment (49.8 +/- 28.3% to 17.1 +/- 15.7%, p < 0.01). Additionally, the levels of interleukin 1 beta and interleukin 8 were significantly higher in BAL fluid of these patients than those in the healthy volunteers (p < 0.025, p < 0.01 respectively), and correlated with the neutrophil accumulation (r = 0.619, p < 0.05). These cytokines showed a decrease after RXM treatment. These results indicated that RXM acts by reducing pulmonary inflammation through reduction of neutrophil migration to inflammatory sites, and is effective on chronic lower respiratory tract disease.

• Authors: J Kadota, O Sakito, S Kohno, K Abe, R Shirai, K Kawakami, K Iida, T Morikawa, S Kusano, K Hara
• Journal: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases (Kansenshogaku Zasshi) Vol. 68 Issue 1 Pg. 27-33 (Jan 1994) ISSN: 0387-5911 [Print] Japan
• PMID: 8138676 (Publication Type: English Abstract, Journal Article)

Chemical References

• Cytokines
• Roxithromycin

Topics

• Adult
• Aged
• Bronchoalveolar Lavage Fluid (immunology)
• Chronic Disease
• Cytokines (biosynthesis)
• Drug Administration Schedule
• Female
• Humans
• Male
• Middle Aged
• Respiratory Tract Diseases (drug therapy, immunology)
• Roxithromycin (administration & dosage, therapeutic use)