Sneddon's syndrome, anti-cardiolipin antibody and glomerular thrombosis.

Abstract

Sneddon's syndrome, cerebrovascular thrombosis and livedo reticularis, is often a variant of the "primary" anti-phospholipid syndrome (PAPS). We report a woman with PAPS, presenting as Sneddon's syndrome, with renal impairment and glomerular thrombosis on renal biopsy. An IgG anti-cardiolipin antibody (aCL) was identified. The aCL was purified by affinity chromatography, gel filtration chromatography and ion-exchange chromatography, assayed in a modified ELISA and found to be of the type that requires the plasma protein beta 2-GPI to bind aCL. As beta 2-GPI has anticoagulant properties it is postulated that its interaction with aCL has a pathogenic role in the thrombotic lesions associated with aCL.

• Authors: J M Stevens, J E Hunt, A E Seymour, S A Krilis, D J Pugsley
• Journal: Clinical nephrology (Clin Nephrol) Vol. 41 Issue 1 Pg. 18-22 (Jan 1994) ISSN: 0301-0430 [Print] Germany
• PMID: 8137565 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antibodies, Anticardiolipin
• Immunoglobulin G

Topics

• Adult
• Antibodies, Anticardiolipin (analysis)
• Antiphospholipid Syndrome (complications, immunology, pathology)
• Female
• Humans
• Immunoglobulin G (analysis)
• Intracranial Embolism and Thrombosis (etiology, immunology, pathology)
• Kidney Diseases (etiology)
• Kidney Glomerulus
• Pigmentation Disorders (etiology)
• Skin Diseases, Vascular (etiology, immunology, pathology)
• Syndrome
• Thrombosis (etiology)