HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Quantitative SPECT of technetium-99m-DMSA uptake in the kidneys of normal children and in kidneys with vesicoureteral reflux: detection of unilateral kidney disease.

AbstractUNLABELLED:
Quantitative SPECT was used to evaluate renal functional volume (cc), percent of injected dose/cc (%ID/cc) and renal uptake (%) in 11 children with unilateral vesicoureteral reflux grade 3 or greater, and in 19 normal control children without reflux.
METHODS:
Studies were performed 4-6 hr after intravenous injection of 0.750-2 mCi of 99mTc-DMSA.
RESULTS:
Control kidneys (n = 38) had a volume of 99.7 +/- 29.5 cc. The %ID/cc was 0.27 +/- 0.08, and the uptake in one kidney was 24.8% +/- 3.9%. Global renal uptake (right plus left) was 49.6% +/- 7.3%. Functional volume of the control kidneys showed an increase with age, and the %ID/cc showed a steeper decrease with age, resulting in a trend of the kidney uptake to decrease with age. Kidneys with reflux had a decreased kidney uptake of 15.7% +/- 29.5%, compared to age- and sex-matched controls (t = 4.7, p < 0.001). The contralateral kidneys without reflux had a significantly increased total uptake of 33.4% +/- 6.8% as compared to controls (t = 3.44, p < 0.01). Global uptake by the kidneys was 49.2% +/- 8.6% and was not statistically different from controls (t = 1.0, ns).
CONCLUSION:
Our results suggest that SPECT quantitation of 99mTc-DMSA uptake in each kidney separately could be used as a noninvasive method to assess impairment and compensation of the function of the individual kidney in children with vesicoureteral reflux.
AuthorsD Groshar, B Moskovitz, M Gorenberg, A Frankel, J Jerusalmi, P M Livne, D Front
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine (J Nucl Med) Vol. 35 Issue 3 Pg. 445-9 (Mar 1994) ISSN: 0161-5505 [Print] United States
PMID8113893 (Publication Type: Journal Article)
Chemical References
  • Organotechnetium Compounds
  • Technetium Tc 99m Dimercaptosuccinic Acid
  • Succimer
Topics
  • Aging (physiology)
  • Child, Preschool
  • Female
  • Humans
  • Kidney (diagnostic imaging)
  • Male
  • Organotechnetium Compounds
  • Radioisotope Renography
  • Succimer
  • Technetium Tc 99m Dimercaptosuccinic Acid
  • Tomography, Emission-Computed, Single-Photon (methods)
  • Vesico-Ureteral Reflux (diagnostic imaging)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: