Abstract | UNLABELLED: Quantitative SPECT was used to evaluate renal functional volume (cc), percent of injected dose/cc (%ID/cc) and renal uptake (%) in 11 children with unilateral vesicoureteral reflux grade 3 or greater, and in 19 normal control children without reflux. METHODS: RESULTS: Control kidneys (n = 38) had a volume of 99.7 +/- 29.5 cc. The %ID/cc was 0.27 +/- 0.08, and the uptake in one kidney was 24.8% +/- 3.9%. Global renal uptake (right plus left) was 49.6% +/- 7.3%. Functional volume of the control kidneys showed an increase with age, and the %ID/cc showed a steeper decrease with age, resulting in a trend of the kidney uptake to decrease with age. Kidneys with reflux had a decreased kidney uptake of 15.7% +/- 29.5%, compared to age- and sex-matched controls (t = 4.7, p < 0.001). The contralateral kidneys without reflux had a significantly increased total uptake of 33.4% +/- 6.8% as compared to controls (t = 3.44, p < 0.01). Global uptake by the kidneys was 49.2% +/- 8.6% and was not statistically different from controls (t = 1.0, ns). CONCLUSION: Our results suggest that SPECT quantitation of 99mTc-DMSA uptake in each kidney separately could be used as a noninvasive method to assess impairment and compensation of the function of the individual kidney in children with vesicoureteral reflux.
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Authors | D Groshar, B Moskovitz, M Gorenberg, A Frankel, J Jerusalmi, P M Livne, D Front |
Journal | Journal of nuclear medicine : official publication, Society of Nuclear Medicine
(J Nucl Med)
Vol. 35
Issue 3
Pg. 445-9
(Mar 1994)
ISSN: 0161-5505 [Print] United States |
PMID | 8113893
(Publication Type: Journal Article)
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Chemical References |
- Organotechnetium Compounds
- Technetium Tc 99m Dimercaptosuccinic Acid
- Succimer
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Topics |
- Aging
(physiology)
- Child, Preschool
- Female
- Humans
- Kidney
(diagnostic imaging)
- Male
- Organotechnetium Compounds
- Radioisotope Renography
- Succimer
- Technetium Tc 99m Dimercaptosuccinic Acid
- Tomography, Emission-Computed, Single-Photon
(methods)
- Vesico-Ureteral Reflux
(diagnostic imaging)
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