HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Localized lepromatous leprosy and its response to chemo-immunotherapy.

AbstractBACKGROUND:
This is an unusual presentation of lepromatous leprosy (LL) in a young boy, 12 years of age. The study forms part of a large scale immunotherapeutic trial with Mycobacterium w (M.w) antileprosy vaccine. The trial is being conducted in two major hospitals in New Delhi, India.
MATERIALS AND METHODS:
This patient presented with three lesions: one on each forearm and the third on the left leg. He was classified initially as borderline tuberculoid leprosy. Slit-skin smears and histopathology from the lesions proved the diagnosis to be lepromatous leprosy with a bacterial index (BI) 6+. The initial lepromin test was negative. The patient was treated with chemo-immunotherapy (standard multidrug therapy and immunotherapy with Mycobacterium w vaccine).
RESULTS:
Investigations after 1 year (15 months) of multi-drug therapy and three doses of vaccine, showed a remarkable fall in the BI from 6 to 0 in the lesions, a lepromin positivity of 5 mm, and a histological upgrading from lepromatous leprosy to borderline tuberculoid. Immunologic studies at 15 months revealed a good LTT response and high levels of cytokines, specifically IL-2 and IFN-gamma.
CONCLUSIONS:
This report presents an LL patient with disease limited to a few sites. It stresses the importance of slit-smear and biopsy in all patients of leprosy, and it highlights the upgrading observed on administration of chemo-immunotherapy.
AuthorsK R Beena, S A Zaheer, I Guleria, R Mukherjee, G P Talwar, A Mukherjee, V Ramesh, R S Misra
JournalInternational journal of dermatology (Int J Dermatol) Vol. 33 Issue 1 Pg. 64-7 (Jan 1994) ISSN: 0011-9059 [Print] England
PMID8112948 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Bacterial Vaccines
  • Leprostatic Agents
  • anti-leprosy vaccine
Topics
  • Bacterial Vaccines (administration & dosage)
  • Child
  • Combined Modality Therapy
  • Drug Therapy, Combination
  • Humans
  • Leprostatic Agents (administration & dosage)
  • Leprosy, Lepromatous (pathology, therapy)
  • Male

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: