Abstract | BACKGROUND: The biological behavior of paragangliomas is difficult to evaluate by classic histological criteria thus justifying the use of immunohistochemical markers as prognostic factors. METHODS: RESULTS: The atypia and the mitotic rate did not correlate with the behavior of the tumor. Less immunostaining with the anti-S-100 and anti- chromogranin A antibodies was observed in the malignant paragangliomas and in those which were locally aggressive. In the benign tumors the proliferative rate ( PCNA) oscillated between 0.7% and 3.7%, and 40 or less PCNA positive cells were counted in 10 high-power field (HPF) (40x). In malignant and locally aggressive tumors the proliferative rate was 5% or more, with 60 or more cells that were positive for PCNA being found in 10 HPF. CONCLUSIONS:
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Authors | M García Rojo, C Martínez García, C Gamallo Amat, M Patrón Romero |
Journal | Medicina clinica
(Med Clin (Barc))
Vol. 101
Issue 9
Pg. 327-32
(Sep 25 1993)
ISSN: 0025-7753 [Print] Spain |
Vernacular Title | Nuevos factores histopatológicos de valor pronóstico en paragangliomas extraadrenales. Estudio de 9 casos. |
PMID | 8105157
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Chromogranin A
- Chromogranins
- Nuclear Proteins
- Proliferating Cell Nuclear Antigen
- S100 Proteins
- Phosphopyruvate Hydratase
|
Topics |
- Adult
- Chromogranin A
- Chromogranins
(analysis)
- Female
- Humans
- Immunohistochemistry
- Male
- Middle Aged
- Nuclear Proteins
(analysis)
- Paraganglioma, Extra-Adrenal
(chemistry, pathology)
- Phosphopyruvate Hydratase
(analysis)
- Prognosis
- Proliferating Cell Nuclear Antigen
- S100 Proteins
(analysis)
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