Oral sotalol reduces the incidence of atrial fibrillation after coronary artery bypass surgery.

Abstract

Episodes of atrial fibrillation or flutter frequently complicate the postoperative course after coronary bypass surgery. A hundred and one patients undergoing coronary artery bypass surgery were randomized to oral pre- and postoperative treatment with sotalol, a non-selective beta-blocking agent with class-III antiarrhythmic properties (50 patients), or to half the preoperative beta-blocking dose according to the routine of the department (51 patients). Thus, there was no equipotency regarding beta blockade in the two groups. The incidence of atrial fibrillation was 10% in the sotalol group and 29% in the comparison group, p = 0.028. In 10% of the sotalol patients the dose had to be reduced or stopped compared to in none the group given routine treatment. The patients who developed atrial fibrillation were older, but otherwise there was no statistically significant difference between the two groups. Sotalol was effective in reducing the incidence of atrial fibrillation. However, careful titration of the optimal dose should be performed in order to avoid side effects of the beta blockade.

• Authors: U Nyström, N Edvardsson, H Berggren, G P Pizzarelli, K Rådegran
• Journal: The Thoracic and cardiovascular surgeon (Thorac Cardiovasc Surg) Vol. 41 Issue 1 Pg. 34-7 (Feb 1993) ISSN: 0171-6425 [Print] Germany
• PMID: 8103611 (Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Adrenergic beta-Antagonists
• Sotalol

Topics

• Administration, Oral
• Adrenergic beta-Antagonists (administration & dosage)
• Adult
• Age Factors
• Aged
• Atrial Fibrillation (epidemiology, prevention & control)
• Chi-Square Distribution
• Coronary Artery Bypass
• Female
• Humans
• Male
• Middle Aged
• Postoperative Care (statistics & numerical data)
• Postoperative Complications (epidemiology, prevention & control)
• Preoperative Care (statistics & numerical data)
• Sex Factors
• Sotalol (administration & dosage)