Abstract |
Autoimmunity is thought to lead to islet-cell-antibody (ICA) formation in diabetes mellitus. However, we found a mitochondrial gene mutation at nucleotide pair 3243 in 3 of 27 Japanese ICA-positive, initially non- insulin-dependent diabetic patients. All 3 progressed to insulin-dependency within 13-31 months, whereas 5 of the other 24 are non- insulin-dependent after 54-90 months. ICA, at least in these 3 patients, may follow gradual beta-cell destruction due to mitochondrial gene mutation, although the possibility of beta-cells with the mutation being susceptible to autoimmune destruction cannot be excluded.
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Authors | Y Oka, H Katagiri, Y Yazaki, T Murase, T Kobayashi |
Journal | Lancet (London, England)
(Lancet)
Vol. 342
Issue 8870
Pg. 527-8
(Aug 28 1993)
ISSN: 0140-6736 [Print] England |
PMID | 8102670
(Publication Type: Journal Article)
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Chemical References |
- Autoantibodies
- DNA, Mitochondrial
|
Topics |
- Adolescent
- Adult
- Aged
- Autoantibodies
(biosynthesis)
- DNA, Mitochondrial
(genetics)
- Diabetes Mellitus, Type 1
(genetics, immunology)
- Diabetes Mellitus, Type 2
(genetics, immunology)
- Female
- Humans
- Islets of Langerhans
(immunology)
- Male
- Middle Aged
- Point Mutation
- Prospective Studies
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