Sexual precocity due to McCune-Albright syndrome: report of a case.

Abstract

McCune-Albright syndrome is one of the causes of isosexual precocity in girls. Recurrent ovarian cysts are not uncommon in McCune-Albright syndrome; however, treatment for these cysts is still controversial. We report on a six-year-old girl with sexual precocity due to recurrent ovarian cysts. Initially, she received a left salpingo-ophorectomy for an ovarian cyst at the age of two years and one month; the postoperative course was uneventful. Unfortunately, sexual precocity and a cyst on the remaining ovary were noted four years later. A series of studies revealed a hyperpigmented area with an irregular margin on the back and probable fibrous dysplasia of the orbital bone. A luteinizing hormone-releasing hormone test showed a prepubertal response. Cyproterone acetate was tried under the diagnosis of McCune-Albright syndrome, and her secondary sexual characteristics disappeared after treatment.

• Authors: C K Chen, W Y Tsai, J S Lee, Y W Li, F J Hsieh
• Journal: Journal of the Formosan Medical Association = Taiwan yi zhi (J Formos Med Assoc) Vol. 92 Issue 2 Pg. 174-7 (Feb 1993) ISSN: 0929-6646 [Print] Singapore
• PMID: 8101747 (Publication Type: Case Reports, Journal Article)

Topics

• Child
• Female
• Fibrous Dysplasia, Polyostotic (complications)
• Humans
• Ovarian Cysts (complications)
• Puberty, Precocious (etiology)