Hyperreflexia, a condition characterized by contractions of the urinary bladder, is not mediated by a micturition reflex. The contractions can be of neurogenic origin through spinal or supraspinal reflexes or of myogenic origin, independent of neuronal mediation. There is a clear relationship between
hyperreflexia and symptoms such as urgency, frequency,
nocturia and
urinary incontinence.
Therapies to reduce the presence of uninhibited bladder contractions include oral
drug therapy,
instillation drug therapy and parasympathetic nerve ablation. The current study characterizes the ability of
terodiline to inhibit an experimental form of
hyperreflexia and compares the efficacy and potency of
terodiline and other agents on
hyperreflexia and evoked contractions. The results can be summarized as follows: (1)
terodiline inhibits the amplitude of the
hyperreflexia at lower concentrations than it inhibits the frequency of
hyperreflexia; (2)
terodiline had no statistically significant effect on mean blood pressure at any concentration utilized; (3)
terodiline had approximately the same potency for inhibition of 2 and 32 Hz stimulation for both the bladder body and base; (4)
terodiline inhibited the maximum contractile response to
bethanechol and also shifted the curve to the right, demonstrating that
terodiline is a mixed inhibitor, and (5)
terodiline was a noncompetitive inhibitor of KCl.