Effect of calcium citrate supplementation on urinary calcium oxalate saturation in female stone formers: implications for prevention of osteoporosis.

Abstract

In 14 women aged 37-68 y with a history of renal calcium calculi, bone densities were 12.0% below those of age-matched control subjects at the L2-4 lumbar spine (P = 0.007) and 6.4% less at the femoral neck (P = 0.095). A low-oxalate diet was supplemented with 1 g Ca/d as citrate. In 6 mo, plasma 1,25(OH)2D concentrations fell from 53.2 +/- 18.8 to 41.9 +/- 15.2 ng/L (P = 0.02) and parathyroid hormone from 39.1 +/- 17.0 to 30.8 +/- 12.5 ng/L (P = 0.02). Calcium oxalate saturation was 2.15 +/- 1.38 at baseline, 2.27 +/- 1.00 at 1 mo, and 2.06 +/- 1.57 at 6 mo. The increase in urinary calcium at 1 mo from 4.411 +/- 1.87 to 6.514 +/- 2.82 mmol/24 h (P = 0.01) was offset by a parallel increase in citrate excretion from 2.909 +/- 1.45 to 3.455 +/- 1.34 mmol/24 h (P = 0.03). Calcium citrate supplementation did not increase the lithogenicity of the women in this protocol.

• Authors: B S Levine, J S Rodman, S Wienerman, R S Bockman, J M Lane, D S Chapman
• Journal: The American journal of clinical nutrition (Am J Clin Nutr) Vol. 60 Issue 4 Pg. 592-6 (Oct 1994) ISSN: 0002-9165 [Print] United States
• PMID: 8092096 (Publication Type: Clinical Trial, Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Citrates
• Calcium Oxalate
• Citric Acid
• Calcium

Topics

• Adult
• Aged
• Bone Density
• Calcium (urine)
• Calcium Oxalate (urine)
• Citrates (adverse effects, therapeutic use, urine)
• Citric Acid
• Female
• Humans
• Kidney Calculi (chemically induced, urine)
• Middle Aged
• Osteoporosis, Postmenopausal (prevention & control)
• Time Factors