HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Effect of moderate dietary protein restriction on the progression of overt diabetic nephropathy: a 6-mo prospective study.

Abstract
To assess whether moderate dietary protein restriction can delay the progression of overt diabetic nephropathy, 22 subjects with insulin-dependent diabetes mellitus were randomly assigned to an unrestricted protein diet (> 1.6 g.kg body wt-1.d-1) or a moderately protein-restricted diet (0.8 g.kg body wt-1.d-1) and followed prospectively for six mo. Direct isotope methods were used to assess renal function. Protein intake was assessed by measurement of urinary urea nitrogen. The two groups were well-matched for age, sex, duration of diabetes, glycemic control, blood pressure, and degree of renal insufficiency. Patients consuming the unrestricted protein diet (n = 11) showed a progressive decline in glomerular filtration rate of 1.3 mL.min-1.mo-1 with no change in proteinuria. Patients consuming the moderately protein-restricted diet showed a marked decrease in the degree of proteinuria (2.15-1.13 g/d, P = 0.036) and a stabilization of glomerular filtration rate. This occurred independently of changes in blood pressure or glycemic control. Moderate dietary protein restriction can ameliorate progression of overt diabetic nephropathy.
AuthorsF J Raal, W J Kalk, M Lawson, J D Esser, R Buys, L Fourie, V R Panz
JournalThe American journal of clinical nutrition (Am J Clin Nutr) Vol. 60 Issue 4 Pg. 579-85 (Oct 1994) ISSN: 0002-9165 [Print] United States
PMID8092094 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
Chemical References
  • Blood Glucose
  • Dietary Proteins
  • Triglycerides
  • Urea
  • Cholesterol
Topics
  • Adult
  • Blood Glucose (metabolism)
  • Blood Pressure
  • Cholesterol (blood)
  • Diabetes Mellitus, Type 1 (diet therapy, physiopathology)
  • Diabetic Nephropathies (physiopathology, prevention & control)
  • Dietary Proteins (administration & dosage)
  • Female
  • Glomerular Filtration Rate
  • Humans
  • Male
  • Prospective Studies
  • Proteinuria (urine)
  • Triglycerides (blood)
  • Urea (urine)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: