Abstract |
Ten patients with low cardiac output syndrome (LCOS, cardiac index [CI] = 1.8 +/- 0.24 L.min-1.m-2, pulmonary artery occlusion pressure [PAOP] = 19 +/- 4 mmHg, systolic arterial pressure [APsys] = 76 +/- 5 mmHg) were treated with catecholamines and nitroglycerin. This therapy achieved stable hemodynamic conditions (CI 2.5 +/- 0.2 L.min-1.m-2, PAOP 14 +/- 5 mmHg, APsys = 110 +/- 17 mmHg). Addition of enoximone (bolus dose 1.0 mg.kg-1 followed by continuous infusion of 7 micrograms.kg-1.min-1) induced an increase of CI to 3.6 +/- 1.3 L.min-1.m-2 (p < 0.05) and of left ventricular stroke work index (LVSWI) from 21.8 +/- 3.6 g.m.m-2 to 29.3 +/- 10.1 g.m.m-2 (p < 0.05). Systemic vascular resistance decreased from 1300 +/- 415 dyn.s.cm-5 to 972 +/- 390 dyn.s.cm-5 (p < 0.01). No alterations of heart rate, mean arterial or pulmonary arterial pressure and PAOP were observed. Likewise, enoximone had no effect on gas exchange. Oxygen consumption index (VO2I) was elevated from 83 +/- 22 mL.min-1.m-2 to 126 +/- 31 mL.min-1.m-2 (p < 0.01) and oxygen delivery index (DO2I) increased from 348 +/- 112 mL.min-1.m-2 to 498 +/- 206 mL.min-1.m-2 (p < 0.05). In contrast, oxygen extraction ration remained unchanged (29 +/- 10% n.s.). Oxygen consumption and delivery were significantly lower during treatment of LCOS with catecholamines and nitroglycerin when compared with a matched group of patients without postoperative cardiac failure.(ABSTRACT TRUNCATED AT 250 WORDS)
|
Authors | T Hachenberg |
Journal | Zeitschrift fur Kardiologie
(Z Kardiol)
Vol. 83 Suppl 2
Pg. 63-8
( 1994)
ISSN: 0300-5860 [Print] Germany |
Vernacular Title | Enoximon in der postoperativen Phase der Herzchirurgie. |
PMID | 8091826
(Publication Type: English Abstract, Journal Article)
|
Chemical References |
- Catecholamines
- Enoximone
- Nitroglycerin
- Oxygen
|
Topics |
- Aged
- Cardiac Output, Low
(drug therapy, physiopathology)
- Catecholamines
(administration & dosage, adverse effects)
- Coronary Artery Bypass
- Drug Therapy, Combination
- Electrocardiography
(drug effects)
- Enoximone
(administration & dosage, adverse effects)
- Female
- Heart Failure
(drug therapy, physiopathology)
- Hemodynamics
(drug effects, physiology)
- Humans
- Infusions, Intravenous
- Male
- Middle Aged
- Nitroglycerin
(administration & dosage, adverse effects)
- Oxygen
(blood)
- Postoperative Complications
(drug therapy, physiopathology)
- Pulmonary Gas Exchange
(drug effects, physiology)
- Stroke Volume
(drug effects, physiology)
- Vascular Resistance
(drug effects, physiology)
|