Abstract |
The main objective of this multicenter study was to compare the efficacy of an increase in dose and of a synergic combination in the 68 patients out of 126 (54%) with hypertension (DBP between 95 and 120 mm Hg after 2 weeks of placebo) who did not respond (DBP > or = 95 mmHg) to a 4-week treatment of 20 mg per day of lisinopril. Patients were randomized to receive a 4-week double-blind treatment of either 40 mg per day of lisinopril or the combination of 20 mg of lisinopril and 12.5 mg of hydrochlorothiazide per day. Mean reductions of systolic (inter-group comparison: p = 0.08) and diastolic BP (p = 0.006) as well as the proportion of responders (82% versus 45%, p < or = 0.01) were greater with the lisinopril- hydrochlorothiazide combination than with 40 mg of lisinopril. Tolerance was good in the 3 groups. The administration of a synergic combination is justified when hypertension is not controlled by a monotherapy.
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Authors | J J Leduc, O Madonna, V Gressin |
Journal | Therapie
(Therapie)
1994 Jan-Feb
Vol. 49
Issue 1
Pg. 17-22
ISSN: 0040-5957 [Print] France |
Vernacular Title | Evaluation du lisinopril et de l'association lisinopril-hydrochlorothiazide dans l'hypertension artérielle légère à modérée. Groupe de Travail Prinzide. |
PMID | 8091360
(Publication Type: Clinical Trial, English Abstract, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Hydrochlorothiazide
- Lisinopril
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Topics |
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Synergism
- Drug Therapy, Combination
- Humans
- Hydrochlorothiazide
(administration & dosage, therapeutic use)
- Hypertension
(drug therapy, physiopathology)
- Lisinopril
(administration & dosage, therapeutic use)
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