Abstract |
The effect of cimetidine on gastrointestinal (GI) symptoms in patients taking non-steroidal anti-inflammatory drugs was studied in a multicentre, double-blind, placebo-controlled 4 week trial. Five hundred and seventy osteoarthritis patients received cimetidine 400 mg bid or placebo. Seventy-nine % in the cimetidine group had no GI symptoms at week 4 compared to 72% in the placebo group (p = 0.07). Only 5.6% in the cimetidine group reported heartburn compared to 19.2% in the placebo group. Diarrhoea was more pronounced in cimetidine treated patients; 18.5% compared to 2.7%. In a subgroup of patients with previous GI discomfort on NSAID therapy (N = 123), 63% reported disappearance of symptoms in the cimetidine group compared to 45% in the placebo group (p = 0.05). In patients with GI symptoms starting NSAID therapy and in patients on NSAID with a heartburn problem, cimetidine seems to be of value.
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Authors | H E Rugstad, K E Giercksky, G Husby, I Holme |
Journal | Scandinavian journal of rheumatology
(Scand J Rheumatol)
Vol. 23
Issue 4
Pg. 177-82
( 1994)
ISSN: 0300-9742 [Print] England |
PMID | 8091142
(Publication Type: Clinical Trial, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Cimetidine
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Anti-Inflammatory Agents, Non-Steroidal
(adverse effects)
- Cimetidine
(therapeutic use)
- Double-Blind Method
- Female
- Gastrointestinal Diseases
(chemically induced, prevention & control)
- Humans
- Male
- Middle Aged
- Osteoarthritis
(drug therapy)
- Time Factors
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