The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study in Finland.

Abstract

The U.S. National Cancer Institute and the Finnish National Public Institute jointly sponsored a large double-blind, placebo-controlled primary-prevention trial to examine the effects of vitamin E and beta-carotene supplementation on reducing the incidence of lung cancers in male smokers, ages 50-69 years. Supplementation did not result in a significant reduction in lung cancer, and a higher incidence of lung cancer was observed in the group receiving beta-carotene. These results should be examined within the context of the population studied before they are cited as definitive.

• Authors: J Blumberg, G Block
• Journal: Nutrition reviews (Nutr Rev) Vol. 52 Issue 7 Pg. 242-5 (Jul 1994) ISSN: 0029-6643 [Print] United States
• PMID: 8090376 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• beta Carotene
• Vitamin E
• Carotenoids

Topics

• Aged
• Carotenoids (therapeutic use)
• Cohort Studies
• Double-Blind Method
• Finland (epidemiology)
• Follow-Up Studies
• Humans
• Lung Neoplasms (epidemiology, etiology, prevention & control)
• Male
• Middle Aged
• Registries
• Smoking (adverse effects)
• Vitamin E (therapeutic use)
• beta Carotene