Prognostic significance of cell proliferation in mucoepidermoid carcinomas of the salivary gland: clinicopathological study using MIB 1 antibody in paraffin sections.

Abstract

Mucoepidermoid carcinomas of salivary gland origin have an uncertain clinical course not directly predictable by histomorphology. The MIB 1 antibody, which detects Ki-67 antigen in formalin-fixed, paraffin-embedded tissues, was used to study cell proliferation in these tumors. An MIB 1 index was developed to express the percentage of MIB 1-positive proliferating cells, and the results were compared with histomorphological tumor grade and clinical outcome. All patients with MIB 1 indices lower than 10% in their primary tumors had a favorable clinical outcome. Most patients with MIB 1 indices higher than 10% developed a recurrent or metastasizing disease. All patients who died of their tumor or who had persistent tumor had MIB 1 indices higher than 10%. Thus, the MIB 1 index defines two virtually nonoverlapping forms of the disease, an indolent one and an aggressive one. Cell proliferation in mucoepidermoid carcinomas, assessed with the MIB 1 antibody, thus represents a significant prognostic factor for improving the accuracy of conventional histological grading.

• Authors: A Skalova, H Lehtonen, K von Boguslawsky, I Leivo
• Journal: Human pathology (Hum Pathol) Vol. 25 Issue 9 Pg. 929-35 (Sep 1994) ISSN: 0046-8177 [Print] United States
• PMID: 8088769 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal

Topics

• Adult
• Aged
• Aged, 80 and over
• Antibodies, Monoclonal
• Carcinoma, Mucoepidermoid (pathology, physiopathology)
• Cell Division
• Female
• Follow-Up Studies
• Humans
• Immunoenzyme Techniques
• Male
• Middle Aged
• Paraffin Embedding
• Prognosis
• Salivary Gland Neoplasms (pathology, physiopathology)