HOMEPRODUCTSCOMPANYCONTACTFAQResearchDictionaryPharmaSign Up FREE or Login

Gastric subcellular organelle fragility and impaired gastric energy charge levels in rats with caerulein-induced acute pancreatitis: protective effect of anti-ulcer agent, teprenone.

Abstract
When rats were given a supramaximal dose of caerulein (infused intravenously at 5 micrograms/kg.h for 4 h) they developed acute pancreatitis characterized by significantly raised amylase levels in the blood. In this model of acute pancreatitis, reduced gastric adenylate energy charge levels were observed, and the leakage of the lysosomal enzyme, cathepsin B, from gastric lysosomes and of the mitochondrial enzyme, malate dehydrogenase, from gastric mitochondria were both significantly accelerated compared with the control group. The intragastric administration of the anti-ulcer agent, teprenone, at a dose of 5 mg/kg (twice before caerulein infusion) significantly inhibited this gastric damage accompanying acute pancreatitis. These results suggest that gastric subcellular organelle fragility may play an important role in the pathogenesis of impaired gastric energy metabolism accompanying acute pancreatitis, and indicate the possible usefulness of teprenone in preventing this gastric damage.
AuthorsT Hirano
JournalThe Journal of international medical research (J Int Med Res) 1994 May-Jun Vol. 22 Issue 3 Pg. 165-70 ISSN: 0300-0605 [Print] England
PMID8088424 (Publication Type: Journal Article)
Chemical References
  • Anti-Ulcer Agents
  • Diterpenes
  • Adenosine Monophosphate
  • Ceruletide
  • geranylgeranylacetone
Topics
  • Acute Disease
  • Adenosine Monophosphate (metabolism)
  • Animals
  • Anti-Ulcer Agents (therapeutic use)
  • Ceruletide (antagonists & inhibitors)
  • Diterpenes (therapeutic use)
  • Drug Evaluation, Preclinical
  • Energy Metabolism (drug effects)
  • Gastric Mucosa (metabolism)
  • Male
  • Organelles (drug effects, enzymology, pathology)
  • Pancreatitis (drug therapy, metabolism, pathology)
  • Rats
  • Rats, Wistar
  • Stomach (drug effects, ultrastructure)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!


Choose Username:
Email:
Password:
Verify Password:
Enter Code Shown: