[Extended reversible global left ventricular contraction dysfunction with symptomless coronary system as effect of cytostatic therapy with 5-fluorouracil].

Abstract

CASE REPORT:

We report on a young female patient suffering from anal-cancer who received simultaneous radiochemotherapy and developed a "hibernating myocardium" during continuous infusion of 5-FU.

CONCLUSION:

In literature the incidence of cardiac complications caused by 5-FU-therapy is found to be between 1% and 10%. Patients with coronary heart disease have a four-fold higher risk. Possible pathogenic mechanisms are spasm of coronary artery, direct cardiotoxicity, immunological reactions and disturbance of the coagulation system.

• Authors: M Unverdorben, S Birkenhake, B Kunkel, J Dunst
• Journal: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] (Strahlenther Onkol) Vol. 170 Issue 8 Pg. 461-6 (Aug 1994) ISSN: 0179-7158 [Print] Germany
• Vernacular Title: Ausgedehnte reversible globale linksventrikuläre Kontraktionsstörung als Folge einer zytostatischen Therapie mit 5-Fluorouracil bei unauffälligem Koronarsystem.
• PMID: 8085212 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Fluorouracil

Topics

• Anus Neoplasms (drug therapy, radiotherapy)
• Combined Modality Therapy
• Coronary Angiography
• Coronary Vasospasm (chemically induced, physiopathology)
• Diagnosis, Differential
• Electrocardiography
• Female
• Fluorouracil (administration & dosage, adverse effects)
• Heart (drug effects, physiopathology)
• Heart Arrest (chemically induced)
• Humans
• Middle Aged
• Myocardial Infarction (diagnosis)
• Risk Factors
• Time Factors
• Ventricular Function, Left