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[Nalbuphine. Comparison of 2 therapeutic regimens for the control of postoperative pain].

Abstract
The therapeutical efficiency and the undesirable effects of Nalbuphine administered to control postoperative pain were compared. Two groups of patients were studied: one group received 10 mg endovenously every 4 h during the first 12 h of the postoperative phase and every 6 h during the following 12 h while the other group received 20 mg with the same intervals. The following variants were evaluated: pain, systolic arterial tension, cardiac frequency, respiratory frequency and undesirable effects. After statistical analysis, a similarity in both groups was confirmed for pain, systolic arterial tension, cardiac frequency, while a significant difference was found in two of the undesirable effects: sedation and sweating. In conclusion, the 10 mg dose is as effective as that of 20 mg to control pain and has less unwanted effects.
AuthorsD Bagilet, J Despósito, A Giovannoni, E Javkin
JournalMedicina (Medicina (B Aires)) Vol. 53 Issue 6 Pg. 503-6 ( 1993) ISSN: 0025-7680 [Print] Argentina
Vernacular TitleNalbufina. Comparación de dos regímenes terapéuticos para el control del dolor postoperatorio.
PMID8084247 (Publication Type: Comparative Study, English Abstract, Journal Article)
Chemical References
  • Nalbuphine
Topics
  • Adult
  • Aged
  • Aged, 80 and over
  • Female
  • Hemodynamics (drug effects)
  • Humans
  • Male
  • Middle Aged
  • Nalbuphine (administration & dosage)
  • Pain, Postoperative (drug therapy)
  • Prospective Studies

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