A prospective study of the association of serum neopterin, beta 2-microglobulin, and hepatitis B surface antigenemia with death in infants and children with HIV-1 disease.
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| Abstract |
A high percentage of HIV-1-infected infants and children in Romania are coinfected with hepatitis B virus. Little information is available on the impact of concurrent hepatitis B infection on the course of HIV-1 infection. We conducted a prospective cohort study over 1 year in a group of 68 HIV-1-infected infants and children to determine whether hepatitis B surface antigenemia, neopterin, and beta 2-microglobulin (B2M) predicted death. Among the 44 hepatitis B surface antigen-positive (HBsAg+) subjects at enrollment, 13 (30%) died during 1 year of follow-up. In comparison, two of 24 (8%) HBsAg-negative subjects died (RR = 7.7; p = 0.05). Higher initial serum concentrations of neopterin and B2M were negatively associated with survival. After stratifying by baseline clinical evidence of HIV-related disease, survival was negatively associated with HBsAg+ status (p = 0.04) in 33 children in stage P-2, adjusting for age, serum neopterin, and serum B2M levels. The results of this study suggest that serum neopterin is a marker for severity of clinical illness and that HBsAg+ status increases the mortality rate among children with clinical evidence of HIV infection.
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| Authors | M J Di Franco, D Zaknun, J Zaknun, E Vuja, H P Oswald, P Mayersbach, D Hunter, T D Tosteson, D Trichopoulos, R Schmitzberger |
| Journal | Journal of acquired immune deficiency syndromes (J Acquir Immune Defic Syndr (1988)) Vol. 7 Issue 10 Pg. 1079-85 (Oct 1994) ISSN: 0894-9255 [Print] United States |
| PMID | 8083826 (Publication Type: Journal Article) |
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