Abstract | BACKGROUND: METHODS: Thirteen healthy volunteers, seven male and six female, participated in a randomized, crossover study. Steady-state conditions were obtained after ingestion of 2 g or 6 g mesalazine daily or 2 g olsalazine daily for 1 week. The pH of the duodenum and proximal jejunum was measured by using pH-sensitive, radiotransmitting capsules, the location of which was confirmed by fluoroscopy. RESULTS: No effect of either drug on duodenal pH was detected. Mean duodenal pH ranged from 6.18 to 6.22. The mean pH of the pre-medication proximal jejunum was 6.02. Mesalazine had no significant effect, but olsalazine significantly increased the pH of the proximal jejunum (mean pH, 6.47). CONCLUSIONS: Our results indicate that the effect of olsalazine on jejunal transport of electrolytes and water, observed in experimental studies, also applies to human subjects in steady-state conditions, and adaptation does not occur within 6 days.
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Authors | J Fallingborg, L A Christensen, B A Jacobsen, M Ingeman-Nielsen, H H Rasmussen, K Abildgaard, S N Rasmussen |
Journal | Scandinavian journal of gastroenterology
(Scand J Gastroenterol)
Vol. 29
Issue 6
Pg. 498-500
(Jun 1994)
ISSN: 0036-5521 [Print] England |
PMID | 8079106
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Aminosalicylic Acids
- Mesalamine
- olsalazine
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Topics |
- Adolescent
- Adult
- Aminosalicylic Acids
(pharmacology)
- Duodenum
(drug effects, metabolism)
- Female
- Humans
- Hydrogen-Ion Concentration
- Jejunum
(drug effects, metabolism)
- Male
- Mesalamine
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