Sucralfate suspension as a treatment of recurrent aphthous stomatitis.

Abstract

DESIGN:

A prospective randomized, double-blind, placebo-controlled, cross-over clinical trial.

SETTING:

A university hospital.

SUBJECTS:

Twenty-one patients with symptomatic recurrent aphthous stomatitis (RAS), unresponsive to conventional treatment were enrolled. They were divided into three groups.

INTERVENTION:

In a cross-over trial, the patients received an oral suspension of sucralfate, an antacid solution or a placebo for 2 years.

RESULTS:

After 2 years of follow-up, sucralfate was found to be superior to both placebo and antacid (P < 0.001) with regard to duration of pain, reduction of the healing period, response time to first treatment and duration of remission.

CONCLUSION:

Sucralfate suspension should be added to the armament of treatment modalities of RAS.

• Authors: J Rattan, M Schneider, N Arber, M Gorsky, D Dayan
• Journal: Journal of internal medicine (J Intern Med) Vol. 236 Issue 3 Pg. 341-3 (Sep 1994) ISSN: 0954-6820 [Print] England
• PMID: 8077892 (Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial)

Chemical References

• Antacids
• Suspensions
• Sucralfate

Topics

• Administration, Buccal
• Adolescent
• Adult
• Aged
• Antacids (therapeutic use)
• Child
• Child, Preschool
• Double-Blind Method
• Female
• Humans
• Male
• Middle Aged
• Prospective Studies
• Recurrence
• Stomatitis, Aphthous (drug therapy)
• Sucralfate (administration & dosage, therapeutic use)
• Suspensions
• Treatment Outcome