Effects of amiloride derivatives on the thermosensitivity of an adriamycin-resistant strain of Ehrlich ascites tumor cells.

Abstract

We investigated the effects of amiloride and its derivative MH-12-43 on the thermosensitivity of adriamycin-resistant cells. Effects of hyperthermia at 42 degrees C were enhanced by 0.5 mM amiloride and 0.05 mM MH-12-43, which resulted in no decrease in survival rate by the treatment at 37 degrees C for 120 min. Therefore, the combination of hyperthermia and amiloride derivatives was effective in the adriamycin-resistant cells as well as wild type cells. Further, since the survival rates by the treatment with 0.05 mM MH-12-43 were markedly lower than those with 0.5 mM amiloride from hyperthermia at 42 degrees C, MH-12-43 might be more effective than amiloride.

• Authors: J Asaumi, S Kawasaki, K Nishikawa, M Kuroda, Y Hiraki
• Journal: Anticancer research (Anticancer Res) 1994 May-Jun Vol. 14 Issue 3A Pg. 805-7 ISSN: 0250-7005 [Print] Greece
• PMID: 8074482 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Amiloride
• Doxorubicin
• ethylisopropylamiloride

Topics

• Amiloride (analogs & derivatives, pharmacology)
• Animals
• Carcinoma, Ehrlich Tumor (pathology)
• Cell Survival (drug effects)
• Doxorubicin (pharmacology)
• Drug Resistance
• Hot Temperature
• Tumor Cells, Cultured