Role of metronidazole in radiation therapy (a review of 717 cancer cases).

Abstract

The presence of Hypoxic cells in a tumor decreases their radiosensitivity; which blocks the efficacy of external tele cobalt irradiation. So a study was undertaken in various cancer patients to observe the role of metrnidazole as a selective radiosensitizer. 717 cancer cases were enlisted and were divided into a study and control group. The study group were given metronidazole at a dose of 2 grams orally, 4 hours before each irradiation, (5 days in a week) for 6-7 weeks. The control group were devoid of it. After completion of the treatment, as well as, after 3 years follow-up, it was observed that the patients receiving metronidazole had better treatment response and more number of recurrence free years. Since it is a cheaper drug it can be used freely in the form of a potential radiosensitizer, for external irradiation therapy.

• Authors: D K Acharya
• Journal: Indian journal of medical sciences (Indian J Med Sci) Vol. 48 Issue 5 Pg. 111-6 (May 1994) ISSN: 0019-5359 [Print] India
• PMID: 8070852 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Metronidazole

Topics

• Female
• Humans
• Metronidazole (therapeutic use)
• Mouth Neoplasms (radiotherapy)
• Neoplasms (radiotherapy)
• Uterine Cervical Neoplasms (radiotherapy)