[Biochemical effects of maternal intravenous and intra-amniotic infusion of amino-acids on fetal blood].
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| Abstract |
Before elective cesarean section, 58 normal term's pregnant women were randomly divided into three groups: intravenous (25 women), intra-amniotic (8 women) and control (25 women) groups. The first two groups received maternal intravenous and intra-amniotic infusion of amino acids respectively. The results showed that maternal intravenous administration of amino-acids led to increased levels of amino acids in maternal venous blood and fetal umbilical cord blood plasma (P < 0.05). There was no increase in fetal uptake of amino acids (P > 0.05). The levels of amino acids in fetal umbilical cord blood plasma of the intra-amniotic group were higher than those of the control group (P < 0.05) and intravenous group (P < 0.05). In the intra-amniotic group, the fetal uptake of amino acids increased (P < 0.05). There were no significant differences in fetal umbilical arterious pH, PO2 and PCO2 among the three groups (P > 0.2). Intra-amniotic infusion of 250ml amino-acids did not change the pressure of amniotic cavity (P > 0.2). The authors suggested that intra-amniotic infusion of amino acids, as a paraplacental nutritional route, should be more effective in the treatment for cases of intrauterine fetal growth retardation particularly for those accompanied by severe placental lesions.
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| Authors | A Xing, B Wan, W Zeng |
| Journal | Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao (Hua Xi Yi Ke Da Xue Xue Bao) Vol. 25 Issue 1 Pg. 98-102 (Mar 1994) ISSN: 0257-7712 [Print] China |
| PMID | 8070785 (Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial) |
| Chemical References |
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