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Accelerated nodulosis, pleural effusion, and pericardial tamponade during methotrexate therapy.

Abstract
We describe a patient with seropositive erosive rheumatoid arthritis (RA) who developed accelerated nodulosis, pleural effusion, and pericardial tamponade during methotrexate (MTX) therapy while her arthritis remained inactive. MTX is an effective therapy for the articular manifestations of RA. However, on occasion it may result in triggering the development of extraarticular manifestations of RA.
AuthorsM Abu-Shakra, P Nicol, M B Urowitz
JournalThe Journal of rheumatology (J Rheumatol) Vol. 21 Issue 5 Pg. 934-7 (May 1994) ISSN: 0315-162X [Print] Canada
PMID8064737 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Methotrexate
Topics
  • Arthritis, Rheumatoid (drug therapy)
  • Cardiac Tamponade (chemically induced, diagnostic imaging)
  • Female
  • Humans
  • Methotrexate (adverse effects)
  • Middle Aged
  • Pleural Effusion (chemically induced, diagnostic imaging)
  • Radiography
  • Rheumatoid Nodule (chemically induced, pathology)
  • Ultrasonography

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